Dextromethorphan-Associated Neurotoxicity with Cerebellar Edema (DANCE) syndrome
Toxicosis
Iatrogenic diseases
General description
Dextromethorphan-Associated Neurotoxicity with Cerebellar Edema (DANCE) syndrome is a central nervous system disorder caused by dextromethorphan, a common antitussive medication. Dextromethorphan is a morphinan derivative with sedative and dissociative properties, used as a cough suppressant. It works by directly acting on the cough center in the medulla oblongata, suppressing the cough reflex.
Cerebellar lesion
Non-SOL
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Cerebellum
MRI shows near symmetric hyperintensity in the cerebellar hemisphere on T2-weighted images accompanied by diffusion restriction.
Cerebral white matter lesion
Non-SOL
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CerebrumCerebral white matter