Diffuse neurofibrillary tangles with calcification (DNTC)
Neurodegenerative diseases
Diffuse neurofibrillary tangles with calcification (DNTC) is a rare condition characterized by the following clinical manifestations:
- Early-onset in life
- Higher prevalence in females
- Slowly progressive cortical dementia, initially manifesting with memory impairment
- Various neuropsychiatric symptoms may precede or accompany the dementia syndrome (hallucinations and delirium can occur relatively early in the disease course)
Calcification is a critical imaging feature that distinguishes this disease and is detectable in the early stages, despite normal thyroid and parathyroid function with normal serum calcium and phosphate levels.
Frontotemporal degeneration
Non-SOL
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CerebrumFrontal lobe
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CerebrumTemporal lobe
Atrophy is localized in the frontotemporal lobes, with reduced cerebral blood flow in these regions on perfusion single-photon emission computed tomography (SPECT) imaging.
Calcificaction
Non-SOL
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Dentate nucleus
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Globus pallidus
Calcification involves the globus pallidus and the dentate nucleus.