Huntington's disease
Neurodegenerative diseases
General description
Huntington's disease is an autosomal dominant disorder caused by an abnormal expansion of CAG triplet repeats in the huntingtin gene.
The typical age of onset ranges from the 3rd to the 5th decade of life, with the initial manifestations often involving chorea, accompanied by bradykinesia, rigidity, and cognitive and psychiatric disturbances.
Caudate and putaminal atrophy
Non-SOL
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Caudate nucleus
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Putamen
Neuroimaging findings in Huntington's disease demonstrate severe atrophy of the bilateral caudate nuclei and putamen. Additionally, proton density-weighted imaging (PDWI) sequences typically reveal hyperintensities within the atrophied caudate nuclei and putamen.